O'Flaherty, Cristian

O'Flaherty, Cristian

Research member

Degrees & Professional Designations: DVM, PhD

Academic Position:
- Associate Professor, Department of Surgery (Division of Urology), McGill University
- Associate member, Department of Pharmacology and Therapeutics, McGill University
- Associate member, Department of Medicine, (Division of Experimental Medicine), McGill University

Primary Appointment: Department of Surgery (Division of Urology)

Research interests:
• Redox signaling in spermatogenesis, epididymal maturation and sperm activation
• Regulation of apoptosis in the testis
• Phosphorylation events involved in sperm activation
• Male infertility
• Toxicology of male reproduction

Current Research Grants:

Cristian O’Flaherty graduated from University of Buenos Aires, Argentina with a DVM and PhD in animal physiology and biochemistry degrees. During his postdoctoral training at McGill University, he characterized new phosphorylation events associated with human sperm capacitation and performed studies on the impact of chemotherapy on sperm chromatin structure of cancer survivors. He is dedicated to the study of biology of male reproduction. He has been studying sperm function in many animal models including bovine, equine, porcine, canine species and in humans. Dr O’Flaherty conducted studies regarding the role of reactive oxygen species (ROS) and specific dehydrogenases in the activation of bull spermatozoa and the impact of exogenous antioxidants to improve cryopreservation protocols in many domestic animals species. The main goal of his research program at the Royal Victoria Hospital, MUHC is to elucidate the molecular mechanisms allowing the production of healthy spermatozoa. Particularly, his research focuses on the redox regulation by reactive oxygen species triggering and modulating these mechanisms during spermatogenesis, epididymal maturation and sperm activation. Dr O’Flaherty has made contributions on new antioxidant enzymes called peroxiredoxins and their involvement in the physiology of human spermatozoa and their impairment in male infertility.

Contact Information
Mailing Address:
MUHC GLEN - Royal Victoria Hospital Site
1001 Decarie Boulevard, Room EM0.3212
Montreal, Quebec
H4A 3J1

Tel. No.: (514) 934-1934, ext.: 35410
Fax No.: (514) 933-4149

Recent/Key Publications:
Publications indexed on PubMed-